SportInjuryRISQ

What is SportInjuryRISQ and
SportInjuryRISQPLUS

 

SportInjuryRISQ is a unique genetic test for both professional and recreational athletes. It focuses on two important components of an individual's sport activities: risk of sustaining chronic Achilles tendinopathy and anterior cruciate ligament tears and on the general state of the cardiovascular system. The main and most important asset of the SportInjuryRISQ test is that in addition to your genetics it also takes into account environmental factors that are very important as well.

Besides the analysis of 16 DNA sequence variants within 10 clinically relevant genes, test includes information about your medical history, injuries, physical activity, diet, blood tests, etc.

It should be noted that the susceptibility to injury and cardiovascular complications are affected by many environmental and genetic factors. Presence of specific changes in your DNA is not enough to develop an injury, it simply increases the risk for the individual. For individuals who have a genetic predisposition, while living in a risk environment, the likelihood of injury and cardiovascular complications is higher.

SportInjuryRISQ test is not a diagnostic test, and it can not tell whether you will get anterior cruciate ligament injury or Achilles tendon or if you will develop cardiovascular disease. It is designed to assess your risk for such complications and it allows you to customize your lifestyle and training in order to avoid the injuries and cardiovascular complications.


The impact of genetics on susceptibility to injury of
anterior cruciate ligament and Achilles tendon

 

Achilles tendon and anterior cruciate ligament (ACL) tears, the most common injuries of the soft connective tissue, lead to a longer recovery period and absence from training and competitions. Prior knowledge of the individual susceptibility to connective tissue damage allows you to tailor the appropriate way of training and reduce the likelihood of connective tissue injuries.

Acute and chronic musculoskeletal soft tissue injuries that also include anterior cruciate ligament ruptures and Achilles tendinopathy are commonly found in sports and physical activities associated with the performance of a given profession. The formation of such injuries is not only one source. Susceptibility for anterior cruciate ligament injuries and Achilles tendon are affected by many intrinsic and extrinsic factors. Intrinsic are those that we can not change (genetics, age, gender, biomechanics, previous injuries ...), on the other hand the extrinsic factors (environmental, occupation, diet, exercise, use of medications ...) can be influenced and changed.

Tendons and ligaments are collagenous structures consisting mostly of water and collagen fibers; binder and tendon cells (and their DNA) have an impact on the identification of mechanical loads and the reaction to them. For optimal understanding and knowledge of susceptibility to soft connective tissue injuries, it is essential that in addition to environmental factors, we also know genetic background. Well known and widely accepted among scientists is that the individual's susceptibility to sports injuries depends on both genetics and the environment.


Genetics and cardiovascular system

 

Cardiovascular system is an important component of the athletic engagement as it allows the transfer of nutrients and oxygen to the muscle tissue, and the removal of carbon dioxide and lactic acid. Optimal muscle function is also affected by a healthy cardiovascular system.

SportInjuryRISQ test reviews 8 mutations in 5 clinically relevant genes involved in iron and folate metabolism, susceptibility to thrombosis of deep veins and lipid metabolism. The presence of certain DNA changes, in combination with the individual's lifestyle can increase the risk of developing cardiovascular complications, but it can be reduced with some lifestyle changes.


What is the result of the test going to tell me – how should I act

 

The first part of the SportInjuryRISQ test result is the classification of the individuals into high, medium and low group for the risk of developing soft connective tissue injury. The second part focuses on the cardiovascular system and the possible interactions between environmental factors (diet, supplements ...) and your genetic background. Based on information from the test results, our experts will tell you what your risk of developing soft connective tissue injurys are as well as advise you on how to regulate environmental factors so that you will avoid the risk of cardiovascular complications.


What is SportInjuryRISQPLUS

 

SportInjuryRISQPLUS is an extended version of the SportInjuryRISQ test. PLUS version of the test additionally determines 12 clinically useful mutations involved in lipid metabolism, folate metabolism, blood clotting, iron metabolism, inflammation (relating to type II diabetes, obesity and hypertension), oxidative stress, detoxification of carcinogens and oestrogen exposure. Results of SportInjuryRISQPLUS are more comprehensive as they include additional information and therefore provide you with an intervention plan that is aimed at improving the quality of your life.


To whom we recommend SportInjuryRISQ
and SportInjuryRISQPLUS

 

SportInjuryRISQ and SportInjuryRISQPLUS are recommended for:

  • Professional athletes
  • Trainers
  • Head of sports clubs and groups
  • Active recreational athletes

Where and how request SportInjuryRISQ and
SportInjuryRISQPLUS

 

online order
  Order test on our website. We will contact you and send you all the needed information as well as a saliva sampling kit and questionnaire to your address.
     
questionnaire
  Once you receive our SportInjuryRISQ kit box, open it and fill out the paper questionnaire or the on-line PDF questionnaire.
     
saliva
  Take a sample of you saliva according to the enclosed instructions. Don't forget to mark your questionnaire and saliva sample with our 13. digit code. Send us back the saliva and the questionnaire (if in paper version).
     
analysis
  Our team prepares the analyses.
     
report
  Once the report is ready we will notify you via e-mail.
     

Saftey

 

DiaGenomi ensures complete safety and anonymity of your data. 13-digit codes are used to mark questionnaire as well as saliva sampler. Since we do not receive any information from who the information and sample are, only 13-digit codes, your data and results are only known by you and our expert team.



Source:

  • Posthumus, M., September, A. V., O'cuinneagain, D., van der Merwe, W., Schwellnus, M. P., & Collins, M. (2009). The COL5A1 gene is associated with increased risk of anterior cruciate ligament ruptures in female participants. The American Journal of Sports Medicine, 37(11), 2234-2240.
  • Collins, M. (2010). Genetic risk factors for soft-tissue injuries 101: a practical summary to help clinicians understand the role of genetics and "personalised medicine." British Journal of Sports Medicine, 44(13), 915-917.
  • Collins, M., Posthumus, M., & Schwellnus, M. P. (2010). The COL1A1 gene and acute soft tissue ruptures. British Journal of Sports Medicine, 44(14), 1063-1064.
  • Posthumus, M., Collins, M., Cook, J., Handley, C. J., Ribbans, W. J., Smith, R. K. W., Schwellnus, M. P., et al. (2010). Components of the transforming growth factor-beta family and the pathogenesis of human Achilles tendon pathology-a genetic association study. Rheumatology, 49(11), 2090-2097.
  • Laguette, M.-J., Abrahams, Y., Prince, S., & Collins, M. (2011). Sequence variants within the 3'-UTR of the COL5A1 gene alters mRNA stability: Implications for musculoskeletal soft tissue injuries. Matrix biology, 30(5-6), 338-345.
  • Posthumus, M., Collins, M., September, A. V., & Schwellnus, M. P. (2011). The intrinsic risk factors for ACL ruptures: an evidence-based review. The Physician and sportsmedicine, 39(1), 62-73.
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  • Kotze MJ and van Rensburg SJ. Pathology supported genetic testing and treatment of cardiovascular disease in middle age for prevention of Alzheimer's disease. Metab Brain Dis 2012; 27: 255-266.

The page was last updated on:
9/29/2015